She was turned, as were her sisters Desdemona and an unidentified sister, from a jaguar to a human. Both Dez and Penelope escaped from their priests because they used them as warriors to die for them and treated them like animals.
During the Fall of Los Angeles, she lost her humanity; however when Dez tried to restore her humanity, she vanished as the Senior Partners turned back time, and her fate was unknown.
Penelope and her sister Dez.
Penelope and her sisters as jaguars.
Penelope and sisters just being turned into humans.