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- "Skilosh, a notoriously violent, asexual, self-replicating species of demon, has the distasteful habit of implanting its demon spawn into the cranium of a human host."
- ―Wesley Wyndam-Pryce[src]
Skilosh demons were a humanoid and asexual demon species recognizable by a fully functional third eye located on the back of their heads.
Skilosh demons were hairless and possessed chalk-white skin, sporting two red stripes running down their foreheads to their eyes, then back behind their ears. Their blood was thick, slimy and yellow-colored. They are capable of speaking human languages as well as their own.
Skilosh reproduced by infecting human hosts with their spawn. Specifically, they injecteced their spawn into the back of host's skull using their long, forked tongues. As a result, in only an hour, the Skilosh spawn manifests in the form of a third eye located in the back of the victim's skull and connected to his/hers visual system. If the gestation was not arrested with the proper ritual, a fully grown Skilosh would burst from the host's skull, killing him or her instantly. Skilosh demon spawns could be removed with a de-oculation powder and an incantation to get rid of the spawn before it hatches. There are several ways to kill Skilosh demons: Wesley identifies hacking them to pieces as one and other methods shown were a shotgun blast to the chest, getting hit by a car and a severe beating.