|This article is about the event. For the episode, see The Yoko Factor.|
- Spike: " It's called the Yoko Factor. Don't tell me you've never heard of the Beatles?"
- Adam: "I have. I like Helter Skelter."
- Spike: "What a surprise. The point is, they were once a real powerful group. It's not a stretch to say they pretty much ruled the world. When they broke up, everybody blamed poor Yoko. The truth is, the group broke itself up. She just happened to be there.. You know how it is with kids. They go off to college, they grow apart. Way of the world."
- — The Yoko Factor
After allying with Adam to get the Initiative's anti-human aggression chip out of his head, Spike came up with a plan to split Buffy and the Scoobies apart from one another, deeming it "the Yoko Factor" in reference to Yoko Ono, who was blamed by many for the breakup of the Beatles, as part of Adam's master plan.
Using the existing tensions between the Scoobies to his advantage (Buffy's intense focus on her newfound relationship with Riley, Giles' feelings of uselessness, Xander's lack of direction, and Willow's recent gay relationship with Tara), Spike paid visits to Willow, Xander, and Giles, playing on their insecurities and strained relationships to successfully turn them against one another.
However, in a subsequent encounter with Spike, Buffy put two and two together when Spike let too much information slip, and reunited with her friends to stop Adam. While sneaking into the Initiative base, Buffy, unsettled by how easily Spike had turned them against one another, and not wanting to lose her friends, reconciled completely with the rest of the gang.